Smooth Your Laugh Lines

Defyne your expression with Restylane® Defyne, and invest in yourself to help maintain natural movement to help keep you looking like you. Crafted with new XpresHAn Technology™, Restylane® Defyne is an FDA approved injectable to help smooth out deep laugh lines (nasolabial folds and marionette lines). Using innovative cross-linking technology, Restylane® Defyne is a hyaluronic acid dermal filler that is able to help restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions.

What is Restylane® Defyne?

Restylane® Defyne is an injectable crafted with XpresHAn Technology™ to correct deeper nasolabial folds (smile lines) and marionette lines (lines that run from the corner of your mouth toward the chin. The unique cross-linking of the gel in Restylane® Defyne is also designed to help support your facial expressions—for natural-looking results that help maintain your natural movement.

Restylane® Defyne (and Restylane® Refyne) are the only fillers on the market that have been shown in clinical trials to help maintain natural movement and expressions. They use a unique new technology called XpresHAn, which is a cross-linking technology for areas of the face that have a lot of movement. This creates a very natural appearance that before may have not been possible. Defyne is for deep wrinkles and folds, whereas Refyne and other fillers may be for more subtle correction of lines and wrinkles.

Am I a Candidate?

You may be a candidate for Restylane® Defyne if you have unwanted nasolabial folds or marionette lines and wish for a non-surgical approach to reducing their appearance. During your initial consultation, your providers will discuss if Restylane® Defyne is the best treatment for you. 

What Results Will I See?*

Patients can expect to see a reduction in the appearance of nasolabial folds and marionette lines. Restylane® Defyne has been proven to last for up to 12 months. 97% of subjects treated were satisfied with their results and would do it again, and 95% said they would recommend it to a friend.

Is There Any Downtime?*

There is no downtime associated with Restylane® Defyne treatments.

What is the difference between and Restylane® Defyne and Restylane® Refyne?

Both of these fillers last up to 12 months compared to regular Restylane® which lasts approximately 6-8 months. These fillers are flexible and are ideal for the areas of the face that have a lot of movement, which we call “High Motion”. Restylane® Refyne was approved for the treatment of moderate to severe (we prefer to see this as more subtle signs of aging) facial wrinkles and folds, and Restylane® Defyne for the treatment of moderate to severe, deep facial wrinkles and folds. Each of these gel fillers is made with a flexible hyaluronic acid filler that uses XpresHAn Technology – creating gels that offer a wide range of flexibility and support. Like memory foam – this gel moves and molds with your natural movement and then returns to its natural shape – so it is ideal for the areas of the face where there is a lot of movement.

How does Restylane® Defyne compare to Restylane® Lyft?

Restylane® Defyne is designed to help maintain a natural look through a range of facial expressions and movement while smoothing out deeper lines and wrinkles, especially smile and marionette lines. Restylane® Lyft is designed to focus more on the mid-face to help restore lost volume. Restylane® Lyft is also formulated with 0.3% lidocaine to help reduce pain at the injection site.

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*Individual Results May Vary