Bioxx™ is a holistic 3 phase treatment protocol that addresses skin quality, thickness,
restoration, and muscle relaxation, well beyond the limitations of Botox™, and without
using neurotoxins.

Phase 1 – Tightening + Ablation uses focused Ultrasound + Ablation to perform a
deep structural lift to the muscle and skin to dramatically rejuvenate the appearance of
the forehead tissue in just one visit.  

Phase 2 – Muscle Toning + Wrinkle Reduction applies high-intensity facial electrical
stimulation (HIFES) synchronized with radiofrequency (RF) energy to the forehead. This
induces 75,000 supramaximal muscle contractions to tone and strengthen the frontalis
muscle while stimulating collagen and elastin, providing up to 37% wrinkle reduction,
30% increase in muscle tone, and 23% natural lift without paralysis, in just 4 weekly
treatments.

Phase 3 – Biostimulation + Repair (incorporated in muscle toning sessions) uses
micro-channeling sessions to deliver a blend of bioactive ingredients directly into the
skin’s deeper layers, targeting dynamic forehead wrinkles caused by muscle
contractions, as well as address skin health and repair. The process involves three
sessions spaced two weeks apart, allowing for gradual repair and tissue relaxation. On
the final visit, a sealing agent is applied to lock in the benefits and enhance longevity.  

Unlike Botox™, which temporarily paralyzes muscles, Bioxx™ promotes natural
relaxation through peptide signaling, collagen and elastin stimulation, thickening of the
dermal layer, improved muscle function and health, increased cellular repair, and
hydration, resulting in smoother skin with improved vitality.

Bioxx™ offers wrinkle reduction and relaxation but from a totally different approach.
Botox™ stops muscles from contracting only, with no added skin rejuvenation benefits,
in fact, its the opposite, as skin health, lymphatics, and skin thickness decline with
continued use of Botox™. With Bioxx™, you receive many added benefits like skin thickening, DNA repair, resurfaced rejuvenated skin, and muscle rebuilding for a more
holistic, comprehensive result, even with movement, much like youthful skin. Bioxx™ is
non-toxic, with no risk of "frozen" expressions, and promotes long-term skin health and
longevity rather than temporary paralysis.

During the full Bioxx™ protocol, an initial corrective treatment is implemented using a
non-invasive high-intensity focused Ultrasound energy to lift and strengthen forehead
muscles. This rebuilds healthy muscle tone from chronic Botox™ use, preventing
atrophy while maintaining smooth skin. Immediately after the muscle portion, we focus
on skin rejuvenation using ablation to dramatically resurface and improve the look and
youthfulness of the forehead skin in just one visit. Together, these functions include
muscle lifting, collagen and elastin remodeling, and dramatically improved texture and
tone, with results lasting 12+ months.

Phase 2 – Muscle Toning + Wrinkle Reduction uses high-intensity facial electrical
stimulation (HIFES) synchronized with radiofrequency (RF) energy applied to the
forehead. HIFES induces supramaximal muscle contractions to tone and strengthen the
frontalis muscle while RF stimulates collagen and elastin production. Clinical results
include up to 37% reduction in wrinkle depth, 30% increase in muscle tone, and 23%
natural lift after a series of four 20-minute sessions. This approach relaxes dynamic
forehead lines without paralysis, improves skin firmness, and prevents the muscle
atrophy sometimes seen with repeated Botox.

This mild protocol on phase 2 of Bioxx™ focuses on biostimulation, bio-rejuvenation,
tissue relaxation, skin thickening, DNA Repair, and a healthier glow. Regenerative
ingredients include:

• Polylactic Acid (PLLA): A biocompatible polymer that stimulates collagen production,
  helping to thicken the skin and improve elasticity over time.
• Hyaluronic Acid (HA): A natural humectant that deeply hydrates the skin, plumping it
  from within and supporting tissue repair.
• Calcium Hydroxyapatite (CaHa): A mineral compound that provides structural support,
  aiding in dermal regeneration and volume restoration.
• DMAE: An antioxidant that firms the skin and improves muscle tone, contributing to a
  lifted appearance.
• Hydrolyzed Hibiscus Extract: A plant-derived ingredient that relaxes facial muscles
  naturally, reducing wrinkle depth.
• Acetyl Hexapeptide-8 and Acetyl Hexapeptide-30:  Potent peptides that inhibit
  neurotransmitter release, mimicking Botox by relaxing dynamic wrinkles without
  injections.
• Polynucleotides: DNA fragments from wild salmon that promote cellular regeneration
  and improve skin resilience.
• Acetyl Heptapeptide-9: A peptide complex that boosts collagen synthesis and skin
  barrier function.
• Copper Tripeptide-1: A signaling peptide that accelerates wound healing and anti-
  aging processes.
• Recombinant Collagen Type III: A bioengineered form of collagen that enhances skin
  structure, promoting firmness and reducing fine lines.

These ingredients work synergistically: Peptides relax muscles, PLLA and collagen
thicken the dermis, HA hydrates, and antioxidants protect against damage. Results
typically include a 20-40% reduction in wrinkle depth, smoother texture, and a radiant
glow after the three sessions, with effects building progressively.

DNA Repair builds upon biostimulaton by incorporating repair elements to address long-
term skin quality issues often seen with repeated Botox use, such as "lifeless" skin from
reduced movement, impaired lymphatics, limited oxygen/nutrient delivery, and
decreased blood flow. Added ingredients include:

• Epitalon: A tetrapeptide that supports telomere health, promoting cellular longevity and
  skin vitality.
• GHK-Cu (Copper Peptide): A multi-functional peptide that repairs DNA damage,
  reduces inflammation, and stimulates collagen/elastin production.
• NAD+ (Nicotinamide Adenine Dinucleotide): A coenzyme that boosts cellular energy,
  aiding in DNA repair and combating oxidative stress.
• Methylene Blue: An antioxidant that enhances mitochondrial function, improving skin
  metabolism and radiance.

These function to revitalize "dormant" skin areas by repairing genetic damage,
enhancing lymphatic drainage, and restoring blood flow. Results include not just wrinkle
relaxation but also revived skin luminosity, better texture, and reduced signs of aging
like dullness—often a 40-60% visible improvement in overall skin quality after the
protocol.

Clients often see noticeable improvements in forehead wrinkles within 2-4 weeks, with
peak results at 6-8 weeks. Expect relaxed expression lines, thicker and more resilient
skin, reduced fine lines, and a natural, healthy glow from improved hydration and
circulation. Studies on similar peptide-based treatments show up to 30+% improvement
skin quality and lines, that can last 3-6 months with proper skincare maintenance,
though touch-ups may be recommended for ongoing benefits. It’s ideal for those
seeking a subtle, natural alternative to Botox without the "frozen" look.

Repeated Botox use (≥5 years) is documented to cause:

• 19 % average loss of skin thickness
• Reduced collagen I & III density
• Decreased sebaceous gland activity → loss of natural glow
• Impaired fibroblast function & slower healing
• Frontalis muscle atrophy & brow ptosis
• Compensatory wrinkles elsewhere from muscle imbalance
• Increased skin crepiness and laxity
• Reduced lymphatic drainage, blood flow, and oxygenation

Bioxx™ directly counters every single one of these with collagen and elastin stimulation,
biostimulators, DNA-repair peptides, and active muscle re-toning.

Bioxx™ is performed by our award-winning team with 30 years of experience in medical
aesthetics. All ingredients are biocompatible, naturally derived, and suitable for most
skin types, with minimal risks. Common side effects include 5-7 days of redness and
peeling from the initial skin tightening and ablative treatment, then temporary redness,
slight swelling, or pinpoint bleeding from the micro-channeling protocol, resolving within
24 hours. Rare issues like mild bruising are possible but uncommon. Always disclose
medical history during consultation to ensure safety.

Bioxx™ is perfect for adults seeking a natural Botox™ alternative, those with mild-to-
moderate forehead wrinkles, or anyone wanting to improve skin quality without
injectables. It's not recommended for pregnant individuals, those with active skin
infections, those who want a “frozen” forehead, or those with severe allergies.

Yes — many clients use Bioxx™ as an “exit strategy” from Botox™ or alternatively to
keep skin quality high between toxin sessions. Adding Bioxx™ to Botox™ will
counteract some of the skin degrading effects of Botox, while rejuvenating, thickening,
and repairing damaged and aged skin. It’s a 360 total skin approach, versus just putting
the muscle ‘asleep’ like with Botox™ alone.

Yes — however fillers are not designed for the forehead area, and are for all other
places on the face.

Biostimulation + DNA Repair 

• 3-6 months, repeat one quarterly
  Muscle Toning +  Wrinkle Relaxation → 9-12 months
• Lifting + Ablation Treatment (single)→ 12 months

Initial visit one session: one week of redness and peeling on the forehead
Micro-channeling protocol: mild redness, splotchy for 12–48 hours.  
Rare (<2 %): light bruising or swelling that resolves in 3–5 days.  
No risk of droopy brows, frozen expression, or resistance/antibody formation as seen
with botulinum toxin.

Active infection or cold sores on forehead

Allergy to metals (micro-channeling protocol only)

Keloid or hypertrophic scarring history  

Pregnancy or breastfeeding  
Shellfish allergy (marine collagen sealing step)  

Uncontrolled autoimmune disease

Those who desire a “frozen” appearance

For the full protocol there are 5 sessions total, with an initial tightening and resurfacing
visit, followed by four weekly sessions involving biostimulation + muscle toning.
Maintenance is typically every 6 for the micro-channeling sessions.

No. Bioxx™ relaxes lines while preserving natural movement and expression — clients
consistently report looking “refreshed and well-rested,” not “done.”

Yes. The ingredients and micro-channeling parameters we use are proven safe across
Fitzpatrick I–VI in multiple studies. The ablation visit, is adapted to be compatible with
darker skin types.

Book your consultation at FACE and discover why Bioxx™ is rapidly becoming the gold-
standard natural Botox alternative.