Selphyller Injectable Gel is an advanced, natural cosmetic treatment that uses your own blood to create a platelet-rich fibrin matrix (PRFM) gel. This gel is injected into the skin to provide subtle volume, smooth fine lines, and enhance overall skin quality. It’s minimally invasive, requires little downtime, and harnesses your body’s healing power for long-lasting, natural results.

A small amount of your blood is drawn and processed in a fast, one-step system. The blood is centrifuged and heated briefly with calcium chloride to form a PRFM gel rich in platelets and growth factors. This gel is injected into areas like under-eyes, cheeks, or smile lines, releasing growth factors for up to 7 days to stimulate collagen production and tissue regeneration, adding subtle volume and improving skin health.

Both Selphyller and Selphyl are from the same company and use PRFM technology. Selphyl, a second-generation PRP available for over 10 years, is more stable than traditional PRP and excels at improving skin texture—think smoothness and tone, better suited for delicate areas like under-eyes, forehead, and periorally (around the mouth) to refine texture.

Selphyller Gel, the newer innovation, is designed for subtle volume enhancement, ideal for filling hollows or softening wrinkles while still supporting skin quality. Its gel form allows a slower release of growth factors compared to Selphyl’s texture-focused benefits. Selphyller Gel is typically used for the low to mid face (e.g., cheeks, nasolabial folds) and temples to add subtle volume.

Selphyller Gel and EZ Gel both use your blood to create PRF-based gels, but their preparation and composition differ:

• Preparation: Selphyller uses a quick, one-step process (20-30 minutes) with centrifugation and brief heating—no extra ingredients. EZ Gel takes longer (45-60 minutes), heating and cooling platelet-poor plasma (PPP) to mix albumin with PRF, adding complexity.
• Composition: Selphyller is a pure PRFM gel, relying on your blood’s fibrin and platelets. EZ Gel adds albumin from your PPP, heated to thicken it into a denser gel.
• Performance: Selphyller releases growth factors for 7 days, offering results up to 2 years. EZ Gel provides immediate volume (3-6 months) and collagen benefits (up to 6 months) but may feel heavier.
• Why Selphyller: Its faster, simpler prep and pure formulation (no albumin) make it ideal for subtle, natural volume that lasts.

Selphyller Gel differs from synthetic fillers like hyaluronic acid (HA) and biostimulating fillers like Sculptra in purpose, mechanism, and application:

• Hyaluronic Acid (HA) Fillers: HA fillers (e.g., Juvederm, Restylane) are synthetic gels that add instant volume by attracting water to plump the skin. They don’t biostimulate—meaning they don’t trigger collagen or elastin production— and their effects fade as the HA breaks down (typically 6-18 months). They’re great for immediate, dramatic volume but lack long-term regenerative benefits.
• Sculptra: Sculptra, made of poly-L-lactic acid (PLLA), is a biostimulating filler that stimulates collagen over time. It’s applied broadly across the mid and lower face or temples to restore volume and improve skin structure, with results emerging gradually over months and lasting up to 2 years. However, it’s synthetic, requires multiple sessions, and isn’t suited for delicate, specific areas.
• Selphyller Gel: Selphyller, a natural PRFM gel, also biostimulates by encouraging collagen and elastin production, but it’s autologous (from your blood) and offers subtle volume instantly plus long-term benefits (6 months to 2 years). Unlike Sculptra’s broad application, Selphyller can target precise areas like under-eyes, neck, or fine lines—spots where Sculptra isn’t typically used due to its thicker consistency and wider focus.
• Complementing HA and Sculptra: HA fillers and Sculptra can work beautifully together with Selphyller. HA provides immediate volume to areas like lips or deep folds, while Sculptra builds a foundation of collagen across larger zones like cheeks or temples. Selphyller then refines the look with subtle volume and biostimulation in delicate areas (e.g., under-eyes or neck), creating a balanced, natural result. Providers often combine them in a single plan for comprehensive rejuvenation.

Selphyller is primarily a biostimulant. It biorevitalizes by hydrating and refreshing skin with growth factors, but its PRFM gel actively stimulates collagen and elastin production over time, offering structural benefits. Unlike HA fillers, it rebuilds your skin naturally, delivering both subtle volume and lasting improvement.

Results can last 6 months to 2 years, depending on the area treated, your lifestyle, and skin condition. The gel’s slow-release matrix extends benefits, with many seeing sustained volume and skin quality improvements.

Most patients need 2-4 sessions, spaced 4-6 weeks apart, for optimal results. Maintenance every 6-9 months can prolong effects.

Selphyller adds subtle volume to precise areas like under-eyes, cheeks, nasolabial folds, or neck. It also smooths fine lines, improves texture, and can address acne scars or support hair restoration—areas where broader fillers like Sculptra aren’t typically applied.

Downtime is minimal—resume normal activities the same day. Mild swelling, redness, or bruising may occur in less than 10% of cases and fade within days. Since it’s autologous, allergic reactions are rare.

Most adults seeking natural volume and skin enhancement qualify, in the most holistic way possible. It’s not suitable for those with blood disorders, active infections, or during pregnancy—consult your provider to confirm.

The process—blood draw, processing with heat, and injection—takes 20-30 minutes. Topical numbing cream can ensure comfort.

Based on PRFM technology:

• Growth factors stay active for up to 7 days, boosting collagen and regeneration.
• Platelet concentration is 2-5 times higher than normal blood, enhancing results.
• Over 80% of patients report satisfaction with volume and texture after a full course.
• In hair restoration, PRFM increased hair thickness by up to 30% after 3-6 months —similar benefits may apply to skin.

Selphyller is 100% natural, using only your blood—no synthetic materials like HA or PLLA. Unlike HA fillers, it biostimulates for long-term skin health, not just temporary volume that doesn’t stimulate collagen and elastin. Compared to Sculptra, it’s autologous and can target specific areas like eyes and neck without the broader, synthetic approach, offering a subtle, natural look. Still, it pairs well with HA and Sculptra for a full-face strategy.